Macrophage/Dendritic cell progenitor cells (MDPs) are a subset of proliferating cells in the bone marrow that share phenotypic characteristics with myeloid precursor populations. They give rise to dendritic cells (DC) subsets, and typically can not differentiate into granulocytes.
MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and inflammatory monocytes. MDP can differentiate into two subsets of monocytes. These cells are short-lived, extravasate in inflamed tissues in response to injury signals to differentiate into inflammatory dendritic cells and macrophages.
Multiple AncestorsSingle AncestorNo DescendantsDevelops fromPart of Parent