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EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
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LifeMap Discovery

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All in Vivo Cells > Cell Card
Blood
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Hematopoietic Bone Marrow
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Megakaryocytes (HBM)


Bn.BM.MgkCs
Megakaryocytes are extremely large bone marrow cells which contain a highly lobulated nucleus.  These cells give rise to blood platelets (thrombocytes), which are necessary for normal blood clotting. In response to thrombopoietin (TPO) signaling, megakaryocytes grow in size, replicate their DNA without cytokinesis (up to 64N DNA) and release platelets via a budding mechanism.  
Prenatal - Postnatal
Megakaryocytes
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent