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Welcome to
LifeMap Discovery

Watch the introductory video to learn more about our database of embryonic development for stem cell research and regenerative medicine

All in Vivo Cells > Cell Card
Peripheral Blood

Immature B-Cells (PrB)

Immature B cells are precursors of B cells that have a critical role in prevention of auto-immune responses. In most mammals, they are produced in the bone marrow, where they are tested for auto-reactivity, and only then migrate to secondary lymphoid tissues (e.g. spleen, lymph nodes, etc.), where some of them differentiate into mature B cells. The immature B cells develops following thesuccessful recombination of the IgL locus to produce the IgM receptor that is essential for subsequent B cell function at the pre-B cell stage.
Prenatal - Postnatal
Immature B-Cells
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent