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LifeMap Discovery

Watch the introductory video to learn more about our database of embryonic development for stem cell research and regenerative medicine

All in Vivo Cells > Cell Card

Primordial Germ Cell Precursors (Epb)

Primordial germ cell (PGC) precursors, the progenitors of the oocytes and spermatocytes, become committed to the germ cell lineage around E6.0, when a group of cells at the proximal region of the epiblast are induced to express Prdm1 (Blimp1).

The pluripotent proximal epiblast cells begin to express Ifitm3 and acquire the ability to form PGCs in response to signals from the extraembryonic tissues, although only a small minority of them become germ cells. At E6.2, about six Ifitm3+ cells in the prospective posterior proximal site of the embryo and directly in contact with the overlying extraembryonic ectoderm begin to show expression of Prdm1.
E6 - E7.25
Primordial Germ Cell Precursors
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent