Primordial germ cell (PGC) precursors, the progenitors of the oocytes and spermatocytes, become committed to the germ cell lineage around E6.0, when a group of cells at the proximal region of the epiblast are induced to express Prdm1 (Blimp1).
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The pluripotent proximal epiblast cells begin to express Ifitm3 and acquire the ability to form PGCs in response to signals from the extraembryonic tissues, although only a small minority of them become germ cells. At E6.2, about six Ifitm3+ cells in the prospective posterior proximal site of the embryo and directly in contact with the overlying extraembryonic ectoderm begin to show expression of Prdm1.
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Multiple AncestorsSingle AncestorNo DescendantsDevelops fromPart of Parent