The collecting duct cells (CDCs) are highly water permeable and are a key component of the collecting duct, the last site where NaCl and water are reabsorbed in the kidney.
In humans, the cortical collecting duct contains a high-resistance epithelium comprised of two cell types. Principal cells are the main Na+ reabsorbing cells and the site of action of aldosterone, K+-sparing diuretics, and spironolactone. Type A and B intercalated cells make up the second cell type in the collecting duct epithelium. Type A intercalated cells mediate acid secretion and bicarbonate reabsorption. Type B intercalated cells mediate bicarbonate secretion and acid reabsorption.
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