IE users: please get the latest browser version at Microsoft Internet Explorer Home Page
if yot already have the latest browser version please verify that your browser settings is not in compatibility mode
The aorta-gonad-mesonephros (AGM) region extends from the umbilical cord to the anterior limb bud and contains the dorsal aorta. At around E11 (mouse), or day 22.5 of gestation (human), multipotent hematopoietic cells from the dorsal aorta colonize the fetal liver (liver bud).
Notch1 signaling is important for hematopoiesis within the AGM but not within the yolk sac.