Mural cells are progenitors of smooth muscle cells (SMCs) and pericytes. As the endothelial tubes invade organ primordia, they become surrounded by locally-derived mesenchymal cells (precursors of mural cells). Hence, the primordium itself contributes the mural cell layer(s) to the developing vessels, which may result in tissue-specific functional and regulatory properties of pericytes, and SMCs. This is in contrast to endothelial cells, which are thought to be of uniform origin.
Varying levels of TGF may activate Alk1 and Alk5 in a differential manner
Multiple AncestorsSingle AncestorNo DescendantsDevelops fromPart of Parent