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EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
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LifeMap Discovery

Watch the introductory video to learn more about our database of embryonic development for stem cell research and regenerative medicine

All in Vivo Cells > Cell Card
Liver
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Intrahepatic Biliary Tree
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Oval Cells (IHBT)


Lvr.IHBT.OvCs
Oval cells are adult liver stem cells derived from activated hepatic progenitor cells that reside in the small terminal bile ducts. Oval cells can differentiate into both hepatocytes and biliary epithelial cells, suggesting that they originate from fetal hepatoblasts that remain undifferentiated in a stem cell niche within the ducts but the exact origin and characteristics of hepatic progenitors in vivo are still obscure. Many of the developmental pathways that regulate hepatogenesis in the embryo, such as HGF, FGF, OSM, TNFa and Wnt control oval cell activation, further supporting suggestions regarding their hepatoblastic origin.

Oval cell differentiation is triggered upon inhibition of hepatocyte proliferation, as seen in cases of severe cirrhosis.
Prenatal - Postnatal
Oval Cells
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent