EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
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Perivenous hepatocytes are exposed to lower oxygen tension, and lower nutrient and hormone levels, than periportal hepatocytes.
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In the periportal regions, b-catenin activity, which is important for zonal gene expression in perivenous hepatocytes, is antagonized by adenomatous polyposis coli (APC).
In mice, liver zonation is evident only in the first week following birth
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