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EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
Content

Welcome to
LifeMap Discovery

Watch the introductory video to learn more about our database of embryonic development for stem cell research and regenerative medicine

All in Vivo Cells > Cell Card
Liver
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Sinusoids
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Sinusoidal Endothelial Cells (SiN)


Lvr.SiN.SECs

Sinusoidal endothelial cells are highly specialized cells, which play important roles in the transfer of solutes between the serum and hepatocytes, as well as in the clearance of soluble macromolecules. Sinusoidal endothelial cells are characterized by a number of specialized features, including clustered fenestrations that may facilitate transfer of factors between the sinusoidal lumen and the surface of the hepatocytes.


The sinusoidal endothelial cells gradually adopt the functional and structural characteristics of mature sinusoids, a change that correlates with modified expression of extracellular matrix components that may influence the maturation process. Although the molecular mechanisms that control growth and maturation of sinusoidal endothelial cells are not well defined, several studies suggest the role of Wnt signaling in their proliferation and differentiation.

Prenatal
Sinusoidal Endothelial Cells
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent