Alveolar Epithelial Type 2 Cells (AEC-2) are large, cuboidal cells whose main function is to produce surfactant. These cells can self-renew and transdifferentiate into AEC-1. AEC-2 can be distinguished at the ultrastructural level by the presence of lamellar bodies and microvilli.
Multipotent cell. SP-C expression is considered a unique marker of mature AEC-2.