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LifeMap Discovery

Watch the introductory video to learn more about our database of embryonic development for stem cell research and regenerative medicine

All in Vivo Cells > Cell Card

Basal Cells (Trc)


Basal cells (BCs) are relatively undifferentiated. In the mouse trachea, the basal cells are long-term progenitor/stem cells that give rise to Clara and ciliated cells both in steady state and after epithelial injury. Well-defined basal cells are not seen in the mouse trachea until around the time of birth.

Like basal cells in other epithelial tissues, such as the skin and esophagus, lung basal cells are characterized by the expression of Trp63 (p63) and cytokeratins 5 and 14 (Krt5/14). Subsets of Keratin-14 (K-14)-expressing BCs in the trachea can restore differentiated epithelium after injury and are distinct from bronchial BCs.

E14.5 - Postnatal
Basal Cells
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent