The cardiac progenitor cells are thought to originate from epiblast cells which reside in the lateral sides of the primitive streak at the early gastrula stage. These cells then ingress into the cranial portion of the primitive streak as part of the mesoderm, and start their bilateral and cranial migration along a semicircular trajectory, with little or no cellular mixing. These cardiogenic progenitor cells later give rise to both the myocardium and the endocardium, in addition to two non-cardiac populations (dorsal mesocardium and the parietal pericardium cells).
The developmental model of a common progenitor for both endocardial and myocardial cells is largely based on work performed in mouse embryos which suggests that this common progenitor population lies within the cardiac mesoderm. These bipotential (or multipotential) cells maintain fate plasticity until a much later time in development than that described using the chick model.
Multiple AncestorsSingle AncestorNo DescendantsDevelops fromPart of Parent