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The dorsal pancreatic bud developes into the head, neck, body and tail segments of the pancreas. As early as E9.0 the dorsal endoderm evaginates into the surrounding mesenchyme to form a recognizable dorsal pancreatic bud (preceding the ventral bud by a day). Both buds subsequently proliferate, stimulated by mesenchymal signals, to form multiple branches and when the gut rotation translocated the ventral bud to the dorsal side, the two buds fuse together around E12.5 to form a functional organ.