Bipotent endocrine/duct progenitor cells are a subset of pancreatic progenitor cells with the potential to differentiate to either endocrine cells or duct cells. These cells reside in a centrally located domain of the pancreatic epithelium. The majority of endocrine cells differentiate from these bipotent progenitor cells during the secondary transition. The fate-potential of these cells correlates with the phenotype of cells known as "trunk" cells (located in the trunk portion of the developing duct-acinar morphology).
An alternative lineage hypothesis exists, however the presented developmental mapping, that involves a bipotent endocrine/duct progenitor cell, is based on the excellent reviews of Pan et al. (2011) and Pierreux et al.(2010).