Browser Not Supported.

IE users: please get the latest browser version at Microsoft Internet Explorer Home Page

if yot already have the latest browser version please verify that your browser settings is not in compatibility mode

Browser: unknown
Version: 0

EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
Content
All in Vivo Cells > Cell Card
Skeletal Muscle
>
Hyoid Arch Muscles
>

Multinuclear Myocytes (HAM)


SkM.HAM.MtMC

Multinuclear myocytes are multinucleated muscle cells formed by fusion of multiple embryonic mononuclear myocytes. During the early stage of embryonic development, these cells are called primary myofibers. Later, secondary myofibers arise upon fusion of fetal myoblasts with primary myofibers. The myofibers then elongate when additional myocytes fuse to their ends. The resulting myofibers are large and can include hundreds of nuclei, where each nucleus reflects the fusion of a single myocyte. The nuclei work in synchrony to produce multiple copies of the genes essential to proper muscle contraction.  The myofiber cell membrane is called the sacrolemma and the cytoplasm is called the sacroplasm. Transverse tubules, or projections of the sacrolemma, extend into the sacroplasm and conduct electrical impulses, triggering muscle contraction. The transverse tubules divide the myofiber into sub-compartments, called myofibrils, which are comprised of multiple myofilaments composed of actin and myosin. Secondary myofibers (~E14.5) acquire differential expression of myosin heavy chain isoforms, which later support fast- versus slow-contracting muscles.

Prenatal
Multinucleated Myotube Cells
Multinuclear Myocytes
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent