Dermal Progenitor Cells (CCtDmt)

Dorsal dermal progenitor cells originate from Pax3/Pax7 double-positive population comprising the somitic dermomyotome. These progenitor cells later form a dermal tissue underlying the ectoderm of the back. Dermal progenitor cells derived from the central part of the dermomyotome migrate minimal distances to their final location, which is in close proximity to the overlying surface ectoderm. Dermal progenitor cells appear to start their specification on E9.5 in mouse embryo. Canonical Wnt/β-catenin signaling is a hallmark of dermal specification. EN1 expression is required for responsiveness to Wnt signaling from neural tube and for acquisition of dermal fate.