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EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
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All in Vivo Cells > Cell Card
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Sacral Dorsomedial Dermomyotome Lip
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Dermal Progenitor Cells (SDML)


Smt.SDML.DrPCs
Dorsal dermal progenitor cells originate from Pax3/Pax7 double-positive population comprising somitic dermomyotome. These progenitor cells later form a dermal tissue underlying the ectoderm of the back. Dermal progenitor cells originating from the dorsomedial lip delaminate and migrate long distances to form a dermal mesoderm layer above the neural tube and the newly formed vertebrae. Dermal progenitor cells appear to start their specification on E9.5 in mouse embryo. Canonical Wnt/β-catenin signaling is a hallmark of dermal specification. En1 expression is required for responsiveness to Wnt signaling from the neural tube and for acquisition of dermal fate.
E9.5 - E10.5
Dermal Progenitor Cells
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent