Elongated spermatids are formed following the elongation phase of spermiogenesis that involves chromatin remodelling, which, in turn, results in nuclear condensation and cessation of transcription.
The manchette is a transient microtubular structure that forms during nuclear elongation. One of the most well characterized cases of male infertility is caused by defective manchette formation.
Chromatin remodeling requires replacement of histones by protamines. In mammals, histones are first replaced by transition proteins (TPs) which are subsequently replaced by protamines (PRMs).
Multiple AncestorsSingle AncestorNo DescendantsDevelops fromPart of Parent