Dental pulp stem cell-derived neural stem cells for treatment of Parkinson's disease

This study aims to test the potential of neural stem cells (NSCs) derived from human exfoliated deciduous teeth in treating Parkinson's disease. The derived NSCs were transplanted into the brains of a Parkinson's disease rat model. The transplanted cells differentiated into tyrosine hydroxylase (TH)-positive neurons that were detected around the needle track in the striatum, 6 weeks post-transplantation. In addition, the NSC-transplanted animals displayed significant behavioral recovery compared with negative controls.