Olfactory ensheathing cells transplantion for treatment of old stroke ischemic patients

This study aims to evaluate the safety, feasibility and therapeutic potential of intracerebral implantation of olfactory ensheathing cells (OECs) in old stroke patients. Recruited patients should undergo the endoscopic surgery for harvesting the olfactory mucosa 1 to 2 months before transplantation. The OECs will be cultured and expanded. Immunohistochemical staining of OECs should be positive for GFAP, S100, and P75. OECs will be transplanted into the peri-infarcted area of the brain.