ALLO-ASC, adipose-derived stem cells for treatment of Crohn's fistula

Adipose-derived stem cells (ASCs) can differente to various types of cells, induce immunomodulatory effects and also feature low immunogenicity. Anterogen has developed a technique for isolating autologous ASCs which have shown good efficacy and safety in Phase I and II studies in the patients with Crohn's fistula. However, Crohn's patients sometimes do not have enough fat to enable adipose tissue extractions for culturing ASCs. Therefore, the investigators have planned to study the safety and efficacy of allogeneic ASCs in patients with Crohn's fistula.