Human umbilical cord mesenchymal stem cells (hUC-MSCs) and human cord blood mononuclear cells (hCB-MNCs) have been shown to have the ability to modulate the immune response and enhance angiogenesis, presenting a novel and promising therapeutic strategy for burn wounds. This study aims to assess the safety and efficacy of hUCMSCs and hCBMNCs transplantation in patients with acute burns.