Embryonic stem cell-derived cardiomyocyte transplantation for myocardial infarction
This study aimed to evaluate the ability of human embryonic stem cells (hESCs) and their cardiomyocyte derivatives (hESC-CMs) to engraft and improve myocardial performance in the rat chronic infarction model. Undifferentiated hESCs or hESC-CMs, were transplanted into rat infarcted hearts, 7-10 days after coronary ligation. Only the hESC-CMs formed stable cardiomyocyte grafts, and improved the typical infarct remodeling process of left ventricle (LV) expansion.
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Embryonic stem cell-derived cardiomyocyte transplantation for myocardial infarction