Encapsulated embryonic stem cell-derived pancreatic progenitor cells for treatment of diabetes

CyT49 is comprised of a human embryonic stem cell (hESC) line differentiated into pancreatic epithelium (PE) and loaded into bilaminar Theracyte™ encapsulation devices. The devices were implanted into a diabetic model in mice and into nude rats. The cells matured and produced insulin in a glucose-sensing manner only in mice. The diabetic mice were salvaged by the implantation.