Embryonic stem cell-derived motor neuron transplantation to treat paralysis

This study aimed to explore the potential of embryonic stem cell-derived motor neurons to functionally replace the motor neuron cells destroyed in a viral-induced rat model for paralysis. Embryonic stem cell-derived motor neurons were transplanted into paralyzed rats, followed by administration of a Rho kinase inhibitor (Y27632) and dibutyryl cyclic adenosine monophosphate (dbcAMP) to foster their survival, growth and axonal extensions. Only treating with dbcAMP led to formation of axons through the spinal cord white matter and into the ventral roots of injured animals.