Browser Not Supported.

IE users: please get the latest browser version at Microsoft Internet Explorer Home Page

if yot already have the latest browser version please verify that your browser settings is not in compatibility mode

Browser: unknown
Version: 0

All in Vitro Cells > Adult Stem / Progenitor Cell card

Mesenchymal Precursor Cells (STRO-3 selected) (Mesoblast)

Mesenchymal precursor cells (MPCs) are isolated from human bone marrow aspirates by density gradient separation, over Ficoll, followed by STRO-3-based immunoselective magnetic activated cell sorting (MACS); cultures are then expanded.  STRO-3 is a monoclonal antibody, which reacts with an epitope of non-specific, human tissue alkaline phosphatase. Stro3 binds to the immunizing stromal cells, but lacks reactivity with peripheral blood-derived mononuclear cells.

Culture-expanded MPCs demonstrate increased gene expression of a range of stem cell markers, when compared to mesenchymal stem cells (MSCs), and exhibit a greater capacity to undergo osteogenic, adipogenic and chondrogenic differentiation.

STRO-3-selected MPCs were plated as single-cell suspensions at a density of 8x103 cells per cm2, in αMEM supplemented with FCS (10%), L-ascorbate-2-phosphate (100 µM), β-mercaptoethanol (50 µM) and Primocin (100 µg/ml).

See additional Stem, Progenitor & Primary Cells for: Bone
Adult Stem / Progenitor Cell
Homo sapiens
Mesenchymal Precursor Cells (STRO-3 selected)