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These human iPS cells were generated from skin cells isolated by biopsy from an ALS patient heterozygous for the rare L144F (Leu144 → Phe) dominant allele of the superoxide dismutase (SOD1) gene. Transgenes encoding KLF4, SOX2, OCT4, and c-MYC were introduced into these fibroblasts by means of vesicular stomatitis virus glycoprotein (VSVg) pseudotyped Moloney-based retroviruses. The cells are positive for pluripotent markers and alkaline phosphatase and negative for the TE-7 fibroblast marker.