Stem cells from human exfoliated deciduous teeth (SHED) are mesenchymal cells, originating from the neural crest, which reside within exfoliated deciduous tooth pulp tissue. These cells have a high growth potential and can differentiate into osteoblasts, adipocytes, and neuron cells. They are isolated based on their high proliferation capacity and their mesenchymal surface markers. Due to their differentiation capacity, they have been tested in tooth reconstruction and regeneration of dentin, bone, muscle, cartilage, cornea, hair and neuronal tissue treatments.