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EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
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LifeMap Discovery

Watch the introductory video to learn more about our database of embryonic development for stem cell research and regenerative medicine

Generation and expansion of erythroid cells

This protocol describes an efficient technique for generation of functional erythroid cells from hESCs, under conditions suitable for scale-up. The resulting cells possess oxygen-transporting capacities comparable with normal red blood cells (RBCs) and respond to changes in pH and in 2,3-diphosphoglycerate concentrations. The resulting cells also undergo progressively shrink in size, and exhibit chromatin condensation, and extrusion of the pycnotic nucleus to form enucleated erythrocytes with a diameter similar to that of normal RBCs.
21-42 days
See additional Protocols for: Blood
Generation and expansion of erythroid cells