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EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
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LifeMap Discovery

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Generation and purification of Nurr1-positive dopaminergic neurons

The following protocol enables the generation of midbrain dopaminergic (MDA) neurons from mouse embryonic stem cells, by co-culture with MS5 cells and administration of defined growth factors followed by isolation of Nurr1+ cells. The derived MDA-like neurons express typical markers and when transplanted into hemiparkinsonian mice, robust recovery is demonstrated.
14-15 days
See additional Protocols for: Dopaminergic Neurons
Generation and purification of Nurr1-positive dopaminergic neurons