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EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
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Generation of dopaminergic neurons using valproic acid and zonisamide

This protocol describes the differentiation of induced pluripotent stem cells (iPS) into dopaminergic (DA) neurons by isolation of PSA-NCAM-positive cells followed by culturing with valproic acid (VPA). In vivo differentiation of the cells can also be performed by transplantation of semi-differentiated cells into rat striata and systemic administration of VPA or zonisamide (ZNS) sodium salt. In both cases, the differentiated cells express typical DA neuron markers.
14 days
See additional Protocols for: Dopaminergic Neurons
Generation of dopaminergic neurons using valproic acid and zonisamide