Recombinant Proteins from LifeMap BioReagents
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This protocol describes the generation of pancreatic progenitors that form functional islets upon transplantation into diabetic mice. In this protocol, ESI-049 cGMP-approved human embryonic stem cells are used. These cells generate a higher proportion of NKX6.1-expressing cells before transplantation, compared to H1 stem cells, and form mature c-peptide-secreting cells in-vivo.