Microarray analysis of liver tissues from obese patients with or without diabetes

Microarray gene expression profiling of liver tissues from obese patients. Liver biopsies were collected from obese subjects (n=13), in the fasting state, during an elective gastric bypass surgery, and  from lean control individuals (n=5) during cholecystectomy. Participants had normal hepatic and thyroid function, no history of excessive alcohol intake, and no other chronic illnesses.

Type 2 diabetes mellitus (T2DM) was diagnosed, based on the oral glucose tolerance test,  in nine of the 13 obese subjects.