Sinus Mucosa -chronic rhinosinusitis vs. Sinus Mucosa - control samples

The differentially expressed gene list was taken from ExpressionAtlas (http://www.ebi.ac.uk/gxa/home), and were calculated as following: • Array data was normalized by the RMA method using Oligo version 1.24.2. • Moderated t-statistics were computed with Limma version 3.16.8 and independent filtering performed using genefilter version 1.46.1, with gene variances as filter statistic. P-values were than adjusted using Benjamini & Hochberg (1995) FDR correction. • Genes were defined as differentially expressed if they have fold change larger than 2 and their adjusted p-value is lower or equal to 0.05. if more than 200 genes pass these threshold, the top 200 genes are presented.
Microarray Analysis
Parent Experiment
Comparisons (1) | Samples (24)

In this microarray experiment, sinus mucosa tissues from pediatric chronic rhinosinusitis (CRS) patients (n=9) were compared to those of control samples (n=9).

Sinus tissue was obtained from CRS patients who underwent functional endoscopic sinus surgery for CRS refractory to medical management. Chronic rhinosinusitis was defined as persistent symptoms for more than 3 months, despite antimicrobial and topical nasal steroid therapies.

Children who underwent craniofacial and/or neurosurgical procedures for abnormalities other than sinusitis, served as controls. Exclusion criteria for the control population included a history of sinonasal surgery, current sinonasal infection, sinonasal or allergic symptoms within the previous 3 months, and/or treatment with topical nasal steroids within one month or antihistamines within 3 months prior to surgery. 

The study also contained samples from cystic fibrosis and CRS+cystic fibrosis patients, which are not linked to LifeMap cards. 

Sinus Mucosa -chronic rhinosinusitis  vs. Sinus Mucosa - control samples