Microarray analysis of sinus mucosa tissues from chronic rhinosinusitis patients

In this microarray experiment, sinus mucosa tissues from pediatric chronic rhinosinusitis (CRS) patients (n=9) were compared to those of control samples (n=9).

Sinus tissue was obtained from CRS patients who underwent functional endoscopic sinus surgery for CRS refractory to medical management. Chronic rhinosinusitis was defined as persistent symptoms for more than 3 months, despite antimicrobial and topical nasal steroid therapies.

Children who underwent craniofacial and/or neurosurgical procedures for abnormalities other than sinusitis, served as controls. Exclusion criteria for the control population included a history of sinonasal surgery, current sinonasal infection, sinonasal or allergic symptoms within the previous 3 months, and/or treatment with topical nasal steroids within one month or antihistamines within 3 months prior to surgery. 

The study also contained samples from cystic fibrosis and CRS+cystic fibrosis patients, which are not linked to LifeMap cards.