The mast cell progenitors (MCPs) develop in the bone marrow and are committed to the mast cell lineage. The MCPs are released into the blood where they migrate to different tissues and mature. Mast cells play a pivotal role in immediate hypersensitivity and chronic allergic reactions as well as in inflammation. Mature mast cells are not found in blood but in many connective tissues as well as in mucosal tissues such as in the intestine.
There is some controversy as to the development of the MCPs. Either they develop directly from hematopeitic stem cells (HSCs) in the bone marrow that have lost the self renewal ability, or they develop from the Granulocyte-Monocyte Progenitor Cells (GMPs). In the latter case the cells migrate to the spleen where they become Basophil Mast Cell Progenitors (BMCP) and then they migrate to the intestine and develop into the MCPs.
Multiple AncestorsSingle AncestorNo DescendantsDevelops fromPart of Parent