Cone photoreceptor precursor cells have the potential to form either S cones or M cones in mice and S, M or L cones in humans.
In mice, S cone cells differentiate before M cone cells, beginning shortly after birth, with most differentiated cells localized in the ventral retina. M cone cells begin differentiating about a week later, coinciding with a decrease in the number of S cone cells, and localize to the dorsal retina. In the region where these two gradients overlap, many cones express both photopigments.
In humans, the cone cells are arranged in a mosaic pattern, and express a single type of opsin per cell.
In humans, cones are generated around foetal week (Fwk) 8.
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