EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
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Outer Nuclear Layer
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Cone Precursor Cells (ONL)


Eye.ONL.CnPrCs
Cone photoreceptor precursor cells have the potential to form either S cones or M cones in mice and S, M or L cones in humans. In mice, S cone cells differentiate before M cone cells, beginning shortly after birth, with most differentiated cells localized in the ventral retina. M cone cells begin differentiating about a week later, coinciding with a decrease in the number of S cone cells, and localize to the dorsal retina. In the region where these two gradients overlap, many cones express both photopigments. In humans, the cone cells are arranged in a mosaic pattern, and express a single type of opsin per cell.  

In humans, cones are generated around foetal week (Fwk) 8.
E11.5 - P0
Photoreceptors, Retina
Cone Precursor Cells
Multiple Ancestors Single Ancestor No Descendants Develops from Part of Parent