Tracing experiments using quail-chick chimeras showed that the epicardium cells along with interstitial myocardial fibroblast, cushion mesenchyme and coronary vascular smooth muscle cells are the contributors of the capillary endothelial cells.
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isl1+ progenitors from the second heart field also give rise to endothelial
cells of the coronary tree, as shown by lineage-tracing experiments
Therefore, future experiments employing lineage tracing with epicardial restricted
genetic markers will be required to clarify the potential contribution
of epicardial cells to the coronary endothelium.
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Multiple AncestorsSingle AncestorNo DescendantsDevelops fromPart of Parent