Tracing experiments using quail-chick chimeras showed that the epicardium cells along with interstitial myocardial fibroblast, cushion mesenchyme and coronary vascular smooth muscle cells are the contributors of the capillary endothelial cells.
isl1+ progenitors from the second heart field also give rise to endothelial
cells of the coronary tree, as shown by lineage-tracing experiments
Therefore, future experiments employing lineage tracing with epicardial restricted
genetic markers will be required to clarify the potential contribution
of epicardial cells to the coronary endothelium.
Multiple AncestorsSingle AncestorNo DescendantsDevelops fromPart of Parent