Dermal Progenitor Cells (TDML)

Dorsal dermal progenitor cells originate from Pax3/Pax7 double-positive population comprising somitic dermomyotome. These progenitor cells later form a dermal tissue underlying the ectoderm of the back. Dermal progenitor cells originating from the dorsomedial lip delaminate and migrate long distances to form a dermal mesoderm layer above the neural tube and the newly formed vertebrae. Dermal progenitor cells appear to start their specification on E9.5 in mouse embryo. Canonical Wnt/β-catenin signaling is a hallmark of dermal specification. En1 expression is required for responsiveness to Wnt signaling from the neural tube and for acquisition of dermal fate.