FCRx, bioengineered hematopoietic stem cells for immunological tolerance

FCRx is comprised of donor peripheral blood-derived bioengineered hematopoietic stem cells. Mature graft versus host disease (GVHD)-producing and antigen-presenting cells were removed from the donor blood, for induction of immunological tolerance during organ transplantation and enriched for facilitating cells. Kidney transplant patients treated with FCRx were fully withdrawn from immunosuppression without loss of engraftment and achieved durable chimerism.