EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
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Human mesenchymal stem cell transplantation in mouse model of amyotrophic lateral sclerosis

Human bone marrow mesenchymal stem cells (hMSCs) were transplanted into the lumbar spinal cord of asymptomatic SOD1(G93A) mice, an experimental model of amyotrophic lateral sclerosis (ALS). hMSCs were detected in the spinal cord 10 weeks thereafter, sometimes close to motoneurons, and were rarely GFAP- or MAP2-positive. In female mice, where ALS progression is generally slower when compared to males, astrogliosis and microglial activation were reduced and motoneuron counts were higher following transplantation. Motor tests (Rotarod, Paw Grip Endurance, neurological examination) were significantly improved in transplanted males.
See additional Cell Therapies for: Brain , Motor Neurons , Spinal Cord
Human mesenchymal stem cell transplantation in  mouse  model of amyotrophic lateral sclerosis