EMBRYONIC DEVELOPMENT & STEM CELL COMPENDIUM
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MACI®, cultured chondrocytes for articular cartilage damage in joints

MACI® is a matrix-induced cultured autologous chondrocyte implant, also known as a third-generation autologous chondrocyte implant for treatment of articular cartilage injuries in joints. Chondrocytes are isolated from the patients and grown, in vitro, on a porcine collagen matrix. The physical properties of the type I/III collagen membrane enable easy trimming and handling of the MACI implant, facilitating its application to differently shaped lesions. In addition, it enables cell proliferation and maintenance of the phenotype of differentiated hyaline chondrocytes, while inhibiting the migration of the seeded cells into the joint cavity. Patients with full-thickness lesions of the talus treated with MACI exhibited a significant improvement in clinical and functional aspects and all reported reduced pain.

Additional clinical trials: ACTRN12607000505404 in Australia
See additional Cell Therapies for: Cartilage
MACI®, cultured chondrocytes for articular cartilage damage in joints