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HuCNS-SC®, human central nervous system stem cells for neurological diseases

HuCNS-SC® are a highly purified fetal brain-derived human central nervous system stem cell population, purified by surface marker expression, expanded and then banked. HuCNS-CS have shown neuroprotection abilities.They are being used in clinical trials for treating age-related macular degeneration (AMD), neuronal ceroid lipofuscinosis, Pelizaeus-Merzbacher disease and spinal cord injury. The cells demonstrate long term survival in transplanted neuronal ceroid lipofuscinosis patients and migrate into deeper structures of the brain. HuCNS-SC cells preserve the number of photoreceptors that would otherwise be lost, but also that the surviving photoreceptors appear healthy and normal, and maintain their synaptic connection to other important cells necessary for visual function in a widely used model of retinal degeneration.

Cells were transplanted into into the lateral ventricular space of neonatal NOD-SCID mice brain (10^5-10^6 cells/2ul). The cells survived for 7 months, some proliferated, while others migrated and differentiated. The cells were found in the olfactory system, the hippocampus, the corpus callosum, the striatum and in different areas of the cerebellum and responded to region-specific signals by differentiating into neurons, astrocytes, and oligodendroctes (based on morphology) in a site-specific manner.
See additional Cell Therapies for: Eye , Spinal Cord
HuCNS-SC®, human central nervous system stem cells for neurological diseases