Bone marrow-derived mononuclear and mesencymal stromal cells for chronic renal failure

The aim of the study is to examine whether intraparenchymal injection of bone marrow–derived mononuclear cells and mesenchymal cells can modify the progression of chronic renal failure in rats. Bone marrow-derived cells implanted in the renal parenchyma of nephrectomized rats significantly reduced or stabilized the rate of decline in creatinine clearance. Treatment reduced glomerulosclerosis and proteinuria. Intrarenal injection of mononuclear cells reduced or stabilized the rate of progression of chronic renal failure.