Livers that cannot be donated as whole organs, are processed to liver cells and are injected to treat patients with liver diseases, such as urea cycle defects and acute hepatic failure, to serve as a bridge until whole-liver transplantation.
Clinical and metabolic stabilization was noted in treated pediatric patients. Treatment improved long-term outcomes by bridging the patients to liver transplantation and prevented further neurological deterioration. The liver cell therapy was well tolerated.
Acute liver failure patient treated with liver cells benefited from the treatment which was found to be safe.