Promethera® HepaStem, human adult liver progenitor cells for liver diseases

Promethera® HepaStem is a cell suspension comprised of heterologous human adult liver progenitor cells (HHALPC) isolated from normal adult human liver tissue. The product is indicated for treatment of a variety of liver diseases, from rare inborn metabolic diseases to acquired deficiencies affecting adults, such as fulminant hepatitis or liver fibrosis. Liver parenchymal cells are isolated and further expanded, resulting in an homogeneous progenitor cells population expressing both mesenchymal and hepatocytic markers. Promethera® HepaStem treatment exhibited tolerability and led to repopulation of treated livers by donor cells.