Sickle Cell Anemia (SCA, Sickle-cell disease) is an inherited blood disorder, characterized by abnormal sickle-shaped erythrocytes, caused by a mutation in the β-globin chain of hemoglobin.
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Cell Therapy Approaches
Cell therapy utilizing hematopoietic stem/progenitor cells can lead to re-population of patient bone marrow, where the delivered cells can differentiate into non-diseased normal, functioning erythrocytes.