Ixmyelocel-T are adult bone marrow-derived mononuclear mesenchymal stem cells and monocytes. Ixmyelocel-T is composed of a mixture of cells, specifically myeloid cells (macrophages, granulocytes, monocytes, and mixed myeloid progenitors), lymphoid cells (T cells, B cells, and a mixture of lymphoid precursors) and MSC/stromal cells.
Approximately 50ml of bone marrow is grafted from a patient and CD90+ mesenchymal stem cells and CD14+ monocyte/macrophage progenitor cells are selected and expanded, using single-pass perfusion bioreactors.