Naive human embryonic stem cells (family)

Naive-state human embryonic stem cells (hESCs) are pluripotent stem cells, that, like non-naive or primed hESCs, express pluripotency markers, form teratomas in-vivo and can differentiate into mature cells of all the three germ layers, ectoderm, mesoderm, and endoderm.  When compared to primed hESCs, naive hESCs display a substantial reduction in expression of epigenetic markers. In addition, unlike primed hESCs, naive hESCs survive single-cell cloning and can form cross-species chimeras upon injection into mouse morulas.